ERBB4 and non-small cell lung carcinoma: Furthermore, all three classes of metastatic BRAF mutant NSCLC were significantly enriched for alterations in genes encoding receptor tyrosine kinases, including EGFR and ALK in Class 1; EGFR, ERBB2, ERBB4, FGFR2, and PDGFRA in Class 2; and ERBB3 and FLT3 in Class 3 (Figure 2G–I).