In melanoma, we observed an overlap for gene signatures enriched in Class 2/3 BRAF mutant tumors at the transcriptional and genomic level—these included PI3K/AKT Signaling, Estrogen Response (Early and Late), Mitotic Spindle, G2M Checkpoint, and UV Response Dn (Figure 3 and Figure S2). This evidence concerns the gene AKT1 and melanoma.