FNDC5 and obesity due to melanocortin 4 receptor deficiency: In turn, Moon et al., using both human and mouse in vitro models of obesity-related cancers such as endometrial (KLE and RL95-2), colon (HT29 and MCA38), thyroid (SW579 and BHP7), and esophageal (OE13 and OE33) cancers, did not show that irisin in a range of concentrations between 5 nmol/L to 100 nmol/L had any effect on the migration of cancer cells [55].