Thus, given the limited knowledge regarding HOTAIR SNPs in bladder cancer, this study aims to assess the impact of rs920778 (C > T) and rs12826786 (C > T), which are described as potentially affecting HOTAIR expression [32,33,34,35,36] and are indicated as two of the most promising HOTAIR SNPs to be used as genetic biomarkers in cancer [37,38], in the risk and prognosis of bladder cancer patients. This evidence concerns the gene HOTAIR and cancer.