In a group of soft tissue tumors with shared morphological characteristics, two genetic alterations in GLI1 have been described: GLI1 fusions (in a low frequency of cases studied) and high-level amplifications, often coamplified with neighboring genes in the 12q13.3-q15 region, such as DDIT3/CDK4/MDM2/STAT6 genes [75,76,77,78,79,80,81,104,105,106,107,108]. The gene discussed is CDK4; the disease is soft tissue neoplasm.