After the characterization and localization of the MDM2 gene on chromosome 12 [36], a study was conducted with different histological subtypes of sarcomas, revealing the presence of MDM2 amplification in osteosarcoma, liposarcoma, lipoma, leiomyosarcoma, rhabdomyosarcoma, malignant schwannoma, fibrosarcoma, hemangiopericytoma, and malignant fibrous histiocytoma [33,34,35,36,37,38,39,40,41,42]. The gene discussed is MDM2; the disease is osteosarcoma.