Amplification of MDM2 and CDK4 genes can be detected in various mesenchymal and nonmesenchymal neoplasms [56,77,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108]. The gene discussed is CDK4; the disease is neoplasm.