As well, high lactate and low glucose levels in the hypoxic TME also leads to gene expression changes in CD4+ and CD8+ effector T cells, including inactivation of nuclear factor of activated T cells (NFATs), which in turn leads to suppression of the production of pro-inflammatory IFN-γ needed to potentiate the anti-tumor immune response [47,48]. Here, CD8A is linked to neoplasm.