Interestingly, TSPAN8 has been found to contribute to the migration, invasion, and metastasis of esophageal carcinoma and HCC cells by increasing the expression of a specific isoform (ADAM12m) of ADAM12, which is implicated in the metastasis of various epithelial cancers [118,120]. The gene discussed is TSPAN8; the disease is carcinoma of esophagus.