Prior studies found that either SU-1498, an inhibitor to VEGFR2 at endothelium, or anti-VEGF antibody to tumor cells can inhibit tumor cell adhesion to endothelium [30,33], and our results showed the same inhibition effects of SU-1498 and anti-VEGF although neither of them alter the HS of the BBB or that of MB231, suggesting that their inhibition abilities are independent of HS modulation. This evidence concerns the gene KDR and neoplasm.