During the follow-up of R-RA and NR-RA patients, we found that the percentage of Treg CD39−CD73− cells increased in both groups (p = 0.03), the percentage of B CD39+CD73− cells decreased in R-RA patients only (p = 0.01), and the percentage of CD8+CD39+CD73+ cells and B CD39−CD73+ cells tended to increase in NR-RA patients (p = 0.07 in both). The gene discussed is CD8A; the disease is rheumatoid arthritis.