APOE and open-angle glaucoma: A further analysis of the APOE genotypes according to carrier status (Table 3) showed that the frequency of ε2 carriers (ε2/ε2 and ε2/ε3 genotypes) was also high in the POAGs (4.6%), compared to the 2.0% in the controls, exhibiting more than two-fold increased risk of POAG.