NMNAT2 has two fundamental biological roles: (1) it acts as a NAD+ synthetase by transferring the adenosyl portion of adenosine triphosphate (ATP) to NMN, resulting in the reversible synthesis of NAD+—this function is crucial for neuroprotection and is strongly linked to the development and outcome of malignant tumors [2,3]; (2) moreover, NMNAT2 acts as a molecular chaperone by activating the distinctive ATP site situated in its C-terminal region. The gene discussed is NMNAT2; the disease is cancer.