AKT1 and type 2 diabetes mellitus: Meanwhile, the MAPK signaling pathway (hsa04010), AGE-RAGE signaling pathway in diabetic complications (hsa04933), PI3K-Akt signaling pathway (hsa04151), Ras signaling pathway (hsa04014), and endocrine resistance (hsa01522) are the main signaling pathways of DHM intervention in T2DM.