A study has found that DHM (1.0 g and 0.5 g/kg, BW) could reduce fasting blood glucose, serum insulin, glycosylated hemoglobin levels, and HOMA-IR index, and upregulate IRS-1 (Y612) tyrosine phosphorylation, finally improving insulin resistance in fatty db−/db− mice [11]. Here, INS is linked to Insulin resistance.