AKT1 and cardiomyopathy: As shown in Figure 4F, the KEGG biological pathways significantly enriched in the MET were as follows: PI3K-Akt signaling pathway, cGMP-PKG signaling pathway, MAPK signaling pathway, calcium signaling pathway, cell adhesion molecules, aldosterone synthesis and secretion, regulation of lipolysis in adipocytes, regulation of lipolysis in adipocytes, vascular smooth muscle contraction, adrenergic signaling in cardiomyocyte, and cardiomyopathy.