RENBP and type 2 diabetes mellitus: The signaling pathways associated with T2DM mainly include the PI3K-Akt signaling pathway, IL17 signaling pathway, HIF-1 signaling pathway, MAPK signaling pathway, endocrine resistance, AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, glycerophospholipid metabolism, diabetic cardiomyopathy, arachidonic acid metabolism, etc. The genes associated with these signaling pathways are shown in Table 1.