Interestingly, Xiao YF and colleagues showed that ATO delayed tumor growth, inhibited the microvessel density, downregulated VEGFR-1 and VEGFR-2 expression in gastric tumor xenografts and disturbed the stimulating effect of VEGF-A on the growth of SGC7901 gastric cancer cells [41]. The gene discussed is FLT1; the disease is gastric cancer.