The average number (n = 5) of these regions in each colorectal cancer cell line were as follows: HCT116, 95 in the control group vs. 68 in the anti-PROK1 mAb group (p < 0.05); HT29, 70 in the control group vs. 60 in the anti-PROK1 mAb group (p < 0.05); and DLD-1, 9 in the control group vs. 2 in the anti-PROK1 mAb group (p < 0.05; Table 1). Here, PROK1 is linked to colorectal cancer.