In a study about how MPO and microglia play a role in neurodegenerative Alzheimer’s disease, researchers found that MPO could cause the production of ROS and TNFα, the leading proinflammatory cytokines in this disease, in and around microglia, inducing neuronal apoptosis and necrosis [165]. The gene discussed is MPO; the disease is early-onset autosomal dominant Alzheimer disease.