Thus, we focused on the role of PON1 rs705379, rs705381, rs854560, and rs662, SOD2 rs4880, GPX1 rs1050450, IL1B rs1143623, rs16944, and rs1071676, IL6 rs1800795, IL6R rs2228145, and miR146a rs2910164 in alcohol addiction, and patients’ comorbid psychosymptomatology. The gene discussed is PON1; the disease is Addictive alcohol use.