More specifically, the present study investigated common functional genetic variations in the oxidative stress (PON1, SOD2, and GPX1) and inflammation (IL1B, IL6, IL6R, and miR146a) pathways and their potential association with alcohol addiction and alcohol-related comorbid psychosymptomatology, including obsessive–compulsive, social anxiety, depressive, anxious, and aggressive symptoms. The gene discussed is PON1; the disease is Addictive alcohol use.