As an effective TNF-related apoptosis-inducing ligand (TRAIL) sensitizer, galbanic acid (213) enhanced TRAIL-induced cell apoptosis by inhibiting multidrug resistance 1 (MDR1) and activating caspase and death receptor 5 (DR5) in cisplatin-resistant H460/R non-small-cell lung cancer cells. This evidence concerns the gene TNFSF10 and non-small cell lung carcinoma.