BCL2 and B-cell chronic lymphocytic leukemia: In the meanwhile, umbelliprenin (150) activated caspase-3, -8, and -9 and the proapoptotic protein Bax and reduced the expression of the antiapoptotic protein Bcl-2, caspase-3, -8, and -9, and the proapoptotic protein Bax and reduced the expression of the antiapoptotic protein Bcl2 [230,231], which promoted apoptosis in the Jurkat T-CLL and Raji B-CLL cell lines in a time- and dose-dependent manner [232].