In this context, our previous studies demonstrated that an etoposide-resistant human neuroblastoma (NB) cell line displays high levels of GSH and shows a mono-allelic deletion of the 13q14.3 locus that leads to miRNA 15a/16-1 downregulation and the consequent overexpression of BMI-1 [28]. The gene discussed is BMI1; the disease is neuroblastoma.