Quantitative trait locus mapping and molecular technologies in mice have identified new genetic loci (Ath28, Ath22, Ath26) and associated genes (Soat1, Gpnmb, AKR Pycard) associated with NLRP3 inflammasomes that determine macrophage phenotypes and associated atherosclerosis plaque and pathology [138,139,140]. This evidence concerns the gene NLRP3 and atherosclerosis.