In order to elucidate the association between Egr1 and renal inflammation and fibrosis in DKD, Sheng et al. [108] evaluated the expression levels of Egr1, fibronectin (FN), and tumor necrosis factor-α (TNF-α) in renal tissues of DKD mouse models and HK-2 cells, discovering that they were upregulated both in vivo and in vitro, thereby suggesting that Egr1 can promote the expression levels of the fibrotic marker and inflammatory factors. This evidence concerns the gene TNF and diabetic kidney disease.