FN1 and diabetic kidney disease: In order to elucidate the association between Egr1 and renal inflammation and fibrosis in DKD, Sheng et al. [108] evaluated the expression levels of Egr1, fibronectin (FN), and tumor necrosis factor-α (TNF-α) in renal tissues of DKD mouse models and HK-2 cells, discovering that they were upregulated both in vivo and in vitro, thereby suggesting that Egr1 can promote the expression levels of the fibrotic marker and inflammatory factors.