PFKM and renal fibrosis: Further studies using UUO mice and TGF-β1-treated TCMK-1 cells indicated that miR-21a-5p mitigates renal fibrosis by repressing phosphofructokinase muscle isoform (PFKM) expression, therefore decreasing the rate of glycolysis in TECs and limiting the energy and substrates available for renal fibrosis progression.