In LPS-stimulated HEK293 and HK-2 cell models of AKI, the artificial overexpression of lncRNA cancer susceptibility candidate 2 (CASC2) using Lipofectamine 2000 improved cell survival and reduced cell death, epithelial-mesenchymal transition (EMT), migration, and oxidative stress [91]. The gene discussed is CASC2; the disease is acute kidney injury.