POLE and endometrial carcinoma: The Cancer Genome Atlas (TCGA) Research Network classifies endometrial carcinoma into four molecular groups: DNA polymerase epsilon, catalytic subunit (POLE) mutant or ultramutated (7%), microsatellite unstable (MSI) or hypermutated (28%), no specific molecular profile (NSMP) (also known as p53 wild-type, copy-number-low, or endometrioid) (39%), and p53 mutant (also known as copy-number-high, or serous like) (26%) [56].