NPC1L1 and hepatocellular carcinoma: Moreover, compared with cells treated with Ezetimibe alone, the overexpression of NPC1L1 significantly reduced the cytoplasmic vacuolation induced by Ezetimibe in SNU-449 cells (Figure S6B), further supporting the notion that Ezetimibe induces cytoplasmic vacuolation by targeting NPCL1L1 in HCC cells.