These two bioflavonoids, EGCG and GS, have shown major influences on the NF-κB, mitogen-activated protein kinase (MAPK), epidermal growth factor receptor (EGFR), insulin-like growth factor (IGF), and mechanistic target of rapamycin (mTOR) signaling pathways to provide neuroprotection in neurodegenerative diseases (Table 3). Here, EGFR is linked to neurodegenerative disease.