EGFR and cancer: The EGFR, also known as erythroblastic B1 (ErbB1)/human epidermal growth factor receptor-1(HER-1), is a transmembrane receptor tyrosine kinase implicated in various cancers (e.g., non-small-cell lung cancer, metastatic CRC, glioblastoma, head-and-neck cancer, pancreatic cancer, and breast cancer) [113].