MAPT and Alzheimer disease: Another most widely used animal model of AD is the triple TG mouse model of AD (3xTg-AD) that recapitulates both Aβ and neurofibrillary tangles (NFT) pathologies with incorporation of three mutations such as APP Swedish, microtubule-associated protein tau (MAPT) P301L, and PSEN1 M146V1 associated with FAD.