The NLRP3 (NOD-, leucine-rich repeat- or LRR-, and PYD-containing protein 3) inflammasome is a multimeric protein complex – which is made up of the sensor protein NLRP3, the adaptor protein ASC, and the effector protein pro-caspase-1 – having a role in development of AD [73,74,75]. This evidence concerns the gene NLRP3 and Alzheimer disease.