In the current study, we found that hsa_circ_0092856 was highly expressed in NSCLC cell lines, and that the knockdown of hsa_circ_0092856 inhibited the proliferation, migration, and invasion of H1299 and A549 cells; however, the overexpression of hsa_circ_0092856 promoted the proliferation, migration, and invasion of H1299 and A549 cells, which played this biological function by regulating the expression of eIF3a. This evidence concerns the gene EIF3A and non-small cell lung carcinoma.