Considering the overall incidence rate of thyroid cancer is approximately 11.95 × 10−5 among different countries [34], with FNMTC accounting for about 5% of NMTC, we excluded variants (DUSP16, CHD4, SSPO, NLRP9, ANO2, CTBS, OR51B4) from the general population with allele frequencies higher than 0.001 based on the 1000 Genomes Project and ExAC databases. The gene discussed is SSPOP; the disease is thyroid cancer.