PTEN and glioblastoma: Several mutations associated with GBM malignancy have been identified, including those affecting genes such as Epidermal Growth Factor Receptor (EGFR), Erb-B2 Receptor Tyrosine Kinase 2 (ERBB2), Isocitrate Dehydrogenase 1 (IDH1), Neurofibromin 1 (NF1), Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha (PIK3CA), Phosphoinositide-3-Kinase Regulatory Subunit 1 (PIK3R1), and Phosphatase and Tensin Homolog (PTEN), among others.