RUNX1 and acute myeloid leukemia: In another backtracking study by Wiemels and colleagues, they investigated the prenatal origins of the RUNX1-RUNX1T1 (formerly, AML1-ETO) translocation in childhood AML and detected the fusion gene in newborn DBS in five out of ten patients; two of these positive patients were over the age of 10 years, providing support for a two-hit model of leukemogenesis in some AML patients [36].