The specificity of CA125 is also relatively low (70–80%), and about 6/10 patients with increased CA125 levels do not have ovarian cancer but have different causes, like other malignancies and benign conditions (menstruation, pregnancy, benign ovarian tumors, uterine fibroids, endometriosis, adenomyosis, pelvic inflammatory disease, and liver diseases) [93]. This evidence concerns the gene MUC16 and ovarian benign neoplasm.