The methylation pattern of seven genes, frizzled receptor proteins 1, 2, 4, 5 (SFRP1, 2, 4, 5), SRY-box 1 (SOX1), paired box gene 1 (PAX1), and LIM homeobox transcription factor 1 alpha (LMX1A), revealed the significant correlation between tumor and serum samples and high sensitivity and specificity (73% and 75%) as a screening marker [230]. The gene discussed is SOX1; the disease is neoplasm.