PSMD14 and hepatocellular carcinoma: Moreover, Lv et al. proved that the deubiquitinase, (DUB) 26S proteasome non-ATPase regulatory subunit 14 (PSMD14), an enzyme involved in the senescence mechanism, is significantly upregulated in the tissues of HCC patients, and acts by enhancing vascular infiltration, and tumor metastasis and recurrence [122].