The scientific literature states that STAT4 is involved in the pathogenesis of various autoimmune and inflammatory diseases, and the STAT4 polymorphisms rs10181656, rs7574865, rs7601754, and rs10168266 are associated with various autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SS) [20]. This evidence concerns the gene STAT4 and systemic sclerosis.