Other effects of the expression pattern of TAMs in gliomas include promotion of the invasiveness of CD133+-positive glioma stem cells, and even upregulation of the activity of glycolytic factors such as lactate dehydrogenase A (LDHA) and glucose-6-phosphatase dehydrogenase (G6PD), leading to lactate accumulation. The gene discussed is LDHA; the disease is central nervous system cancer.