ACTA2 and central nervous system cancer: Cancer-associated fibroblasts:Confirmation of the presence of cancer-associated fibroblasts (CAFs) in glioblastomas with proximity to glioma stem cells, endothelial cells and macrophages; significantly shorter overall survival of patients with glioblastomas showing high intratumoral expression of the CAF marker actin alpha 2 (ACTA2) [113].