SIN3A and pulmonary arterial hypertension: A study by Bisserier et al. evaluated the therapeutic efficacy of lung-targeted gene transfer of SIN3a in an MCT-induced PAH rat model, where rats were initially subjected to MCT-induced PAH and then treated with intratracheal delivery of either aerosolized AAV1.hSIN3a or AAV1.Luc as a control [20].