Ultimately, their results suggested that hypermethylation of the BMPR2 promoter region is associated with decreased BMPR2 expression in human patients with PAH, and SIN3a dynamically regulates BMPR2 DNA methylation and expression by modulating the EZH2 and balancing DNMT1/TET1 expression [21]. Here, EZH2 is linked to pulmonary arterial hypertension.