SOD1 and aneurysm: Melatonin treatment in a BAPN-induced mouse model of TAA increased aortic SIRT-1 abundance and activity, Nrf-2 abundance, and SOD activity and this increase in endogenous antioxidant defenses was associated with lower aortic markers of oxidative stress and, importantly, lower incidence of aneurysm formation and rupture [80].