In a murine model of angiotensin-II induced acute aortic dissection, treatment with ursodeoxycholic acid increased vascular Nrf2 expression, which was associated with the decreased expression of pro-oxidant NADPH oxidase and increased expression of antioxidant enzymes including CuZnSOD, MnSOD and catalase, and a resultant marked decrease in the incidence of aortic dissection [81]. This evidence concerns the gene NFE2L2 and Aortic dissection.