The dry AppMM indices in male and female participants with CHF NYHA class III and IV and/or NT‐proBNP levels above 600 pg/mL, in relation to the range of ‘wet’ AppMM indices observed in the normally hydrated control group without heart failure, are shown in Figure6 (A and C for males and B and D for females, respectively). This evidence concerns the gene NPPB and heart failure.