After the identification of the Mas receptor (MasR) as the main mediator of the effects of Ang-(1-7), the protective role of the Ang-(1-7) axis/MasR has been demonstrated against endothelial dysfunction, myocardial ischemia, I/R, ventricular remodeling, and heart failure [124, 125]. Here, MAS1L is linked to myocardial ischemia.