Prescriptions showed a 32% increase in calcium channel blocker (CCB) prescriptions, a 30% increase in beta-blocker prescriptions, a 27% increase in angiotensin-converting enzyme (ACE) inhibitors, vitamin K antagonists (AVAs), and oral antidiabetic drugs, a 24% increase in diuretic prescriptions, and an 18% increase in insulin prescriptions that had indicated decompensation of diabetes [27]. This evidence concerns the gene INS and diabetes mellitus.