We appreciate Japan Brain Bank Net for providing postmortem lumbers of ALS patients, Prof. Shunya Takizawa of Tokai University for fruitful suggestions, Prof. Shinji Hadano of Tokai University for providing SOD1 (G93A) TG mice, and the Support Center for Medical Research and Education of Tokai University for technical assistance. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.