SOD1 and amyotrophic lateral sclerosis: To verify this hypothesis, we analyzed IP7 and its precursor IP6 in the CNS of ALS mouse model SOD1(G93A) transgenic (TG) mice at the three different breeding points, namely 12-week age (before ALS onset), 15-week age (early-middle stage of ALS), and 18-week age (late stage of ALS; Figure 1A).