A recent transcriptome analysis using the TG mice exhibited that mRNA levels of certain genes involved in phosphatidyl inositol metabolic process such as INPP5D (inositol polyphosphate-5-phosphatase D) and INPPL1 (inositol polyphosphate phosphatase like 1) was changed in the spinal cord at ALS disease state (26). Here, INPP5D is linked to amyotrophic lateral sclerosis.