CD8A and metabolic dysfunction-associated steatohepatitis: Splenic CD8+ T cells also demonstrated significant increases in T cell activation and proliferation in response to the Ncf2 peptide under both stimulated (Supplementary Figures 7C, D) and unstimulated conditions supplemented with IL-2 (Supplementary Figures 6E, F) in the Tac NASH model by day 5.