MKI67 and neoplasm: In addition, in the presence of diminished eIF3C levels, expression of Ki67 lowered in Iacs-eif3c-RNA-treated tumor tissues, and the number of TdT-mediated dUTP nick end labeling (TUNEL) positive cells increased, suggesting that this treatment suppressed tumor cell proliferation and augmented apoptosis (Figures 5H, I).