A recent clinical trial of a peptide vaccine targeting a mutation in codon 132, which encodes the IDH1 gene (IDH1(R132H)), containing a common clonal neoepitope presented on MHC II, has shown promising results, with a three-year survival benefit for patients with astrocytomas (WHO grades 3 and 4, NCT02454634 ClinicalTrials.gov) (182). Here, IDH1 is linked to astrocytoma (excluding glioblastoma).