Moreover, CRYAB has proven to have a significant impact in the context of neurotrauma and inflammatory disorders, including stroke, traumatic brain injury, and spinal cord injury (52).Therefore, the dysregulation of CRYAB expression in cardiac and neural tissues is implicated in the pathogenesis of immune-related diseases, inflammation-related conditions, as well as neurodegenerative disorders. Here, CRYAB is linked to brain injury.