Firstly, TAMs affect the phenotypic and functional differentiation of T cells via reversing the anti-tumor cytotoxic T lymphocyte (CTL) and CD4+ Th1 cells to tolerant Th2 cells, Th17 cells, and Tregs cells in a manner dependent on inhibitory cytokines, such as TGF-β and IL-10 (36). This evidence concerns the gene CD4 and neoplasm.