TNF and neoplasm: Moreover, M2-like TAMs induced by tolerant TIME promote tumor angiogenesis through the secretion of pro-angiogenic factors, including VEGFA, FGFs, CXCL8, CXCL12, WNT7B, and BV8, pro-inflammatory cytokines, namely, IL-1β, IL-6, and TNF, as well as pro-angiogenic proteases, including matrix metalloproteinases (MMPs) and cathepsins (141).