During this process, hypoxia and LA regulate the effects of TAMs on the tumor-associated blood vessels via finely tuning the activation of TAMs and stimulating pro-angiogenic gene transcription in a HIF-α–dependent manner, such as VEGFA, TIE2, and neuropilin-1 (NRP1) (62, 136, 137). This evidence concerns the gene NRP1 and neoplasm.