CD4 and neoplasm: Moreover, TCRαβ+CD4−CD8−NK1.1− innate αβ T cells (iαβT) promote M1-like proinflammatory reprogramming of macrophages in a CCR5-dependent manner with enhanced antigen presentation and T-cell chemoattraction, this way improving CD4+ and CD8+ cytotoxic T-cell toward the tumor (112).