High-grade KSS significantly associated with higher probability of achieving DAS28-CRP remission (OR 6.14, 95%CI 1.73-26.10), ACR20 response (OR 5.23, 95%CI 1.51-21.79), ACR50 response (OR 4.33, 95%CI 1.15-21.45) and Boolean2.0 remission (OR 7.93, 95%CI 1.83-56.01) criteria (Figure 2). The gene discussed is CRP; the disease is Kearns-Sayre syndrome.