Our analysis verified that the infiltration of killer cells (mononuclear-macrophages, NK, CD8+T, and MAIT cells) decreased, while the infiltration of helper cells (Th2, Tr1, nTreg, iTreg, NK CD56 bright), playing an immunomodulatory role and inhibiting the function of killer cells, increased in HCC tissues with higher DNAJC8 expression. The gene discussed is DNAJC8; the disease is hepatocellular carcinoma.