Our analysis verified that the infiltration of killer cells (mononuclear-macrophages, NK, CD8+T, and MAIT cells) decreased, while the infiltration of helper cells (Th2, Tr1, nTreg, iTreg, NK CD56 bright), playing an immunomodulatory role and inhibiting the function of killer cells, increased in HCC tissues with higher DNAJC8 expression. The gene discussed is CD8A; the disease is hepatocellular carcinoma.