The critical differences in colonic responses to infection with MC1 TT strain compared to the control strain were: i) elevated gene expression of the inflammasome sensor Aim2 (Figure 3); ii) co-expression of Aim2 and Ifnb1 mRNAs (Figure 3); iii) the proximity of γH2AX-positive nuclei to the Salmonella fljB gene (Figure 4); iv) low levels of oxidative stress-induced DNA damage (Figure 4); and vi) a higher percentage of cells with nuclear p53 (Figure 5). The gene discussed is IFNB1; the disease is infection.