iNKT cells (particularly IL-9-producing iNKT cells) also up-regulate IL-22-producing ILC3s in the mLNs, ultimately preventing DSS-induced colitis under IFN-γ-dysregulated conditions (23), indicating that iNKT cells and ILC3s counter-regulate IFN-γ-mediated intestinal inflammation. The gene discussed is IL22; the disease is colitis.