IFNA1 and infection: Because of its significance in immune response, viruses have developed strategies target STAT proteins to evade the defense during the infection, including porcine reproductive and respiratory syndrome virus (PRRSV), HCV, Ebola Virus that suppresses IFN signaling by leading to phosphorylated STAT1 reduction (Lin et al., 2006; Reid et al., 2006; Yang and Zhang, 2017).