The RNA-seq results showed that MAPT-IT and HCG4 were the most significantly changed host lncRNAs at 24 h.p.i. with SIV NS1 mutant infection, as they were showed higher level in the rSH/2014 NS1 S42P infection group than that in the rSH/2014 infection group (p < 0.01). The gene discussed is MAPT; the disease is infection.