We identified 60 viral genes and 327 bacterial/fungal genes with an AUC of at least 0.9, among them MATR3, CXCL9, and KCNA3 for viral keratitis, and S100A8, CXCL8, and CCL20 for bacterial/fungal keratitis. Here, KCNA3 is linked to fungal keratitis.