SERPINE1 and fungal infectious disease: Pathways that were particularly affected in bacterial/fungal infection included neutrophil activation and degranulation (e.g., CCL20 and CXCR1), leukocyte migration and chemotaxis (e.g., S100A8 and CXCL8), phagocytosis (e.g., CXCL8 and FCER1G), complement activation (e.g., SERPINE1 and C1QA), as well as several cytokine pathways, including TNF and IL17 signaling (e.g., MMP9 and CXCL5) (Figures 1C, D).