The exosomes produced by DCs infected with T. gondii can promote M1 macrophage polarization in the bloodstream by transporting miR-155-5p, and inhibit the suppressor of cytokine signaling 1 (SOCS1) and signal transduction and transcription activating factor (STAT3) signaling pathways to regulate MDSC levels, thereby inhibiting tumor progression in colorectal cancer bearing mice (Lu et al., 2022; Zhu et al., 2022). Here, SOCS1 is linked to neoplasm.