Another component, J18, a recombinant protein based on the surface molecule gp82 of T. cruzi, was confirmed to promote the disruption of the actin cytoskeleton in the tumor cell line Tm5 and affect a series of apoptosis-associated processes including DNA fragmentation, mitochondrial depolarization, and caspase-3 activity, thus inducing apoptosis in tumor cells (Atayde et al., 2008). Here, CASP3 is linked to neoplasm.