Among them, ERVW-1, Suppressyn and Syncytin-2 displayed excellent predictive performance in distinguishing AML from normal samples, with AUC values of 0.977 (95% confidence interval [CI]=0.958-0.996), 0.990 (95% CI =0.977-1.000) and 0.965 (95% CI =0.940-0.990), respectively, by receiver operating characteristic (ROC) curve analysis (Figure 1D). This evidence concerns the gene ERVFRD-1 and acute myeloid leukemia.