SMAD2 and cancer: FGF7 regulated the PPAR signaling pathway (FABP5 and SCD) and the MAPK signaling pathway (FGF1, FGFR2, IL1A, TGFB1, and CSF1) and pathways in cancer (IL7, CD44, SMAD2, and MMP2) may be involved in the formation of follicular cysts (Figure 6A).